HGH or human growth hormone is 191 amino acid sequence, which is normally produced by the human body. It occurs through pulsatile secretion, with most of daily secretion being during sleep.
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HGH can be endogenous and
exogenous. Endogenous HGH is your own growth hormone produced by the pituitary gland. Exogenous HGH is the one coming from outside the body in the form of HGH injections.
Here is what the molecule looks like – it’s a chain of amino acids, connected with peptide bonds.
Growth hormone is responsible for human growth, development of the body, lipid balance, sugar metabolism, bone density, skin quality, and mental health.
Different parts of the amino acid chain are responsible for different effects. And they are produced as separate products.
Fragments from 176 to 191 amino acids are responsible for fat-burning properties of HGH. AOD9604 is a modified version of this sequence with even stronger fat-burning properties (https://pubmed.ncbi.nlm.nih. gov/11146367/
Segment from 1st to 29th aa (CJC 1295, GRF 1-29) is an HGH secretagogue and acts as a hormone inducing the release of endogenous growth hormone.
There are many more peptides available, which are the subject of another full-length guide.
What Forms Of Are Out There?
HGH comes only in injectable form. The oral form of HGH doesn’t exist as the peptide bonds are destroyed in the stomach. The same applies to “HGH” in gel, patch, and spray form – none of them contain real HGH molecules. Beware of misleading marketing for supplements claiming to contain HGH.
How Does Hgh
Work In The Body?
The full 191 amino acid chain of the human growth
hormone provides a full range of effects.
Influences blood sugar levels.
It’s important to note that growth hormone is an antagonist of insulin when it comes to glucose (sugar) metabolism. Insulin decreases blood sugar levels, transporting glucose and other macro and micronutrients to the cells.
Growth hormone increases blood sugar levels. It’s one of the ancient adaptation mechanisms to the lack of food our ancestors encountered. They tended to have prolonged periods of fasting and short periods of the abundance of food as a result of hunting – the so-called fast and feast cycle. When blood sugar level drops, the body releases ghrelin – the hormone of hunger – which in turn induces HGH secretion. HGH
stimulates gluconeogenesis – the process of glucose synthesis from non-carbohydrate sources of energy – primarily fats and proteins.
The ability of GH to induce insulin resistance is significant for the defense against hypoglycemia.
Due to the effect of HGH on sugar levels, prediabetic or
diabetic people shouldn’t take exogenous HGH. It’s also important to monitor your blood sugar levels while you are on HGH.
Helps to burn fat.
The interaction of HGH, blood sugar, and insulin described above is essential to understand in order
to get the most out of HGH. When
blood sugar is low, high HGH levels
lead to fat loss. But it also may lead
to muscle loss as muscle protein can also be used in Gluconeogenesis.
To get the fat loss effects from HGH – achieve high HGH levels when your blood sugar is low. To prevent muscle loss don’t forget to have a protein meal.
Influences protein synthesis.
Growth hormone is vital in protein metabolism. As its name suggests, growth hormone helps children to grow and develop. But the role of growth hormone doesn’t end there. Throughout a person’s life, it
continues to influence the synthesis of proteins – in muscles, skin (collagen, elastin), and hair (keratin). The fall in HGH levels with age is one of the reasons for the deterioration of those tissues.
Strengthens the Immune system.
Growth hormone facilitates the production of T-cells, responsible for the immune response. HGH can also increase the size of the thymus – the gland producing immune cells.
Affects other hormones
Growth hormone may significantly alter thyroid gland function as well as other hormones in the body – testosterone, leptin, cortisol, melatonin, etc.
Improves mental health, cognitive
function, and well-being
Growth hormone has been shown to improve cognition, mood, and overall sense of well-being, especially among growth hormone deficient patients. The nature of this effect is complex and might be attributed to the overall improvement of life quality as well as changes in the hormonal